LARG rabbit pAb

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LARG rabbit pAb

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ES5333

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50 µL	$148.00
100 µL	$248.00

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Overview

Product name:	LARG rabbit pAb
Reactivity:	Human;Mouse;Rat
Alternative Names:	ARHGEF12; KIAA0382; LARG; Rho guanine nucleotide exchange factor 12; Leukemia-associated RhoGEF
Source:	Rabbit
Dilutions:	WB 1:500-2000;IHC-p 1:50-300
Immunogen:	The antiserum was produced against synthesized peptide derived from human ARHGEF12. AA range:449-498
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	173kD
GeneID:	23365
Human Swiss-Prot No:	Q9NZN5
Cellular localization:	Cytoplasm . Membrane . Translocated to the membrane upon stimulation. .
Background:	Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],

Western Blot analysis of RAW264.7 cells using LARG Polyclonal Antibody
Western blot analysis of lysates from RAW264.7 cells, using ARHGEF12 Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of the lysates from HUVECcells using ARHGEF12 antibody.
Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).