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Claudin-19 rabbit pAb
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ES1986
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Claudin-19 rabbit pAb
Reactivity: Human;Rat
Alternative Names: CLDN19; Claudin-19
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human CLDN19. AA range:81-130
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 23kD
GeneID: 149461
Human Swiss-Prot No: Q8N6F1
Cellular localization: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Background: The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010],