KIR3.1 rabbit pAb

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KIR3.1 rabbit pAb

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ES6005

Size：	Price：
50 µL	$148.00
100 µL	$248.00

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Overview

Product name:	KIR3.1 rabbit pAb
Reactivity:	Human;Mouse;Rat
Alternative Names:	KCNJ3; GIRK1; G protein-activated inward rectifier potassium channel 1; GIRK-1; Inward rectifier K(+) channel Kir3.1; Potassium channel; inwardly rectifying subfamily J member 3
Source:	Rabbit
Dilutions:	WB 1:500-2000;IHC-p 1:50-300
Immunogen:	The antiserum was produced against synthesized peptide derived from human GIRK1/KIR3.1/KCNJ3. AA range:151-200
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	56kD
GeneID:	3760
Human Swiss-Prot No:	P48549
Cellular localization:	Membrane; Multi-pass membrane protein.
Background:	Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, at

Western Blot analysis of 3T3 cells using KIR3.1 Polyclonal Antibody
Immunofluorescence analysis of HeLa cells, using GIRK1/KIR3.1/KCNJ3 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from NIH/3T3 cells, using GIRK1/KIR3.1/KCNJ3 Antibody. The lane on the right is blocked with the synthesized peptide.
Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).