Products

mGluR-6 rabbit pAb
One-click to copy product information
ES5678
Size： Price：
50 µL $148.00
100 µL $248.00
Manual Send email to us

Overview

Product name: mGluR-6 rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: GRM6; GPRC1F; MGLUR6; Metabotropic glutamate receptor 6; mGluR6
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human mGluR6. AA range:828-877
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 100kD
GeneID: 2916
Human Swiss-Prot No: O15303
Cellular localization: Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cell projection, dendrite . Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.
Background: glutamate metabotropic receptor 6(GRM6) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012],