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mGluR2 rabbit pAb
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ES5674
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50 µL $148.00
100 µL $248.00
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Overview

Product name: mGluR2 rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: GRM2; GPRC1B; MGLUR2; Metabotropic glutamate receptor 2; mGluR2
Source: Rabbit
Dilutions: Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human GRM2. AA range:241-290
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 96kD
GeneID: 2912
Human Swiss-Prot No: Q14416
Cellular localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse . Cell projection, dendrite .
Background: glutamate metabotropic receptor 2(GRM2) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene