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mGluR1 rabbit pAb
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ES5672
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50 µL $148.00
100 µL $248.00
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Overview

Product name: mGluR1 rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: GRM1; GPRC1A; MGLUR1; Metabotropic glutamate receptor 1; mGluR1
Source: Rabbit
Dilutions: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human GRM1. AA range:251-300
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 132kD
GeneID: 2911
Human Swiss-Prot No: Q13255
Cellular localization: Cell membrane ; Multi-pass membrane protein .
Background: glutamate metabotropic receptor 1(GRM1) Homo sapiens This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013],