Products

MLH3 rabbit pAb
One-click to copy product information
ES5531
Size： Price：
50 µL $148.00
100 µL $248.00
Manual Send email to us

Overview

Product name: MLH3 rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: MLH3; DNA mismatch repair protein Mlh3; MutL protein homolog 3
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human MLH3. AA range:521-570
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 164kD
GeneID: 27030
Human Swiss-Prot No: Q9UHC1
Cellular localization: Nucleus .
Background: This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008],