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ARF GAP3 rabbit pAb
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ES5488
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50 µL $148.00
100 µL $248.00
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Overview

Product name: ARF GAP3 rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: ARFGAP3; ARFGAP1; ADP-ribosylation factor GTPase-activating protein 3; ARF GAP 3
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: Synthesized peptide derived from ARF GAP3 . at AA range: 280-360
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 60kD
GeneID: 26286
Human Swiss-Prot No: Q9NP61
Cellular localization: Cytoplasm . Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side . Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment.
Background: The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008],