MRGX1 rabbit pAb

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MRGX1 rabbit pAb

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ES5449

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50 µL	$148.00
100 µL	$248.00

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Overview

Product name:	MRGX1 rabbit pAb
Reactivity:	Human;Rat;Mouse;
Alternative Names:	MRGPRX1; MRGX1; SNSR3; SNSR4; Mas-related G-protein coupled receptor member X1; Sensory neuron-specific G-protein coupled receptor 3/4
Source:	Rabbit
Dilutions:	WB 1:500-2000;IHC-p 1:50-300
Immunogen:	The antiserum was produced against synthesized peptide derived from human MRGX1. AA range:271-320
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	36kD
GeneID:	259249
Human Swiss-Prot No:	Q96LB2
Cellular localization:	Cell membrane; Multi-pass membrane protein.
Background:	function:Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway.,similarity:Belongs to the G-protein coupled receptor 1 family. Mas subfamily.,tissue specificity:Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.,

Immunofluorescence analysis of HepG2 cells, using MRGX1 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from MCF-7 cells, using MRGX1 Antibody. The lane on the right is blocked with the synthesized peptide.
Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).