Latrophilin-1 rabbit pAb

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Latrophilin-1 rabbit pAb

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ES5265

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50 µL	$148.00
100 µL	$248.00

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Overview

Product name:	Latrophilin-1 rabbit pAb
Reactivity:	Human;Mouse;Rat
Alternative Names:	LPHN1; KIAA0821; LEC2; Latrophilin-1; Calcium-independent alpha-latrotoxin receptor 1; CIRL-1; Lectomedin-2
Source:	Rabbit
Dilutions:	WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Immunogen:	The antiserum was produced against synthesized peptide derived from human LPHN1. AA range:561-610
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Molecular Weight:	163kD
GeneID:	22859
Human Swiss-Prot No:	O94910
Cellular localization:	Cell membrane; Multi-pass membrane protein. Cell projection, axon . Cell projection, growth cone . Cell junction, synapse . Cell junction, synapse, presynaptic cell membrane . Cell junction, synapse, synaptosome . Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts. .
Background:	This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008],

Immunofluorescence analysis of LOVO cells, using LPHN1 Antibody. The picture on the right is blocked with the synthesized peptide.
Immunohistochemical analysis of paraffin-embedded human meningioma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).