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FGFR-3 rabbit pAb
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ES5249
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50 µL $148.00
100 µL $248.00
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Overview

Product name: FGFR-3 rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: FGFR3; JTK4; Fibroblast growth factor receptor 3; FGFR-3; CD antigen CD333
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human FGFR3. AA range:131-180
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 95-130kD
GeneID: 2261
Human Swiss-Prot No: P22607
Cellular localization: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum. The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor.; [Isoform 2]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 3]: Secreted.; [Isoform 4]: Cell membrane ; Single-pass type I membrane protein .
Background: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dys