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APOBEC3A rabbit pAb
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ES5099
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50 µL $148.00
100 µL $248.00
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Overview

Product name: APOBEC3A rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: APOBEC3A; Probable DNA dC->dU-editing enzyme APOBEC-3A; Phorbolin-1
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human APOBEC3A. AA range:27-76
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 26kD
GeneID: 200315
Human Swiss-Prot No: P31941
Cellular localization: Nucleus. Cytoplasm.
Background: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided b