PP2Cε rabbit pAb

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PP2Cε rabbit pAb

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ES4910

Size：	Price：
50 µL	$148.00
100 µL	$248.00

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Overview

Product name:	PP2Cε rabbit pAb
Reactivity:	Human;Mouse;Rat
Alternative Names:	PPM1L; PP2CE; Protein phosphatase 1L; Protein phosphatase 1-like; Protein phosphatase 2C isoform epsilon; PP2C-epsilon
Source:	Rabbit
Dilutions:	WB 1:500-2000;IHC-p 1:50-300
Immunogen:	The antiserum was produced against synthesized peptide derived from human PPM1L. AA range:119-168
Storage:	-20°C/1 year
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	1 mg/ml
Observed Band:	48kD
GeneID:	151742
Human Swiss-Prot No:	Q5SGD2
Cellular localization:	Membrane ; Single-pass type I membrane protein .
Background:	The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],

Western Blot analysis of Jurkat cells using PP2Cε Polyclonal Antibody
Western blot analysis of lysates from Jurkat cells, using PPM1L Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of the lysates from HepG2 cells using PPM1L antibody.
Immunohistochemical analysis of paraffin-embedded human Gastric adenocarcinoma. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).