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MRP2 rabbit pAb
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ES4715
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50 µL $148.00
100 µL $248.00
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Overview

Product name: MRP2 rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: ABCC2; CMOAT; CMOAT1; CMRP; MRP2; Canalicular multispecific organic anion transporter 1; ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human ABCC2. AA range:991-1040
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 175kD
GeneID: 1244
Human Swiss-Prot No: Q92887
Cellular localization: Apical cell membrane ; Multi-pass membrane protein .
Background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008],