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AKAP 220 rabbit pAb
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ES4618
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50 µL $148.00
100 µL $248.00
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Overview

Product name: AKAP 220 rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: AKAP11; AKAP220; KIAA0629; A-kinase anchor protein 11; AKAP-11; A-kinase anchor protein 220 kDa; AKAP 220; hAKAP220; Protein kinase A-anchoring protein 11; PRKA11
Source: Rabbit
Dilutions: Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human AKAP11. AA range:1761-1810
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 211kD
GeneID: 11215
Human Swiss-Prot No: Q9UKA4
Cellular localization: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic in premeiotic pachytene spermatocytes and in the centrosome of developing postmeiotic germ cells, while a midpiece/centrosome localization was found in elongating spermatocytes and mature sperm.
Background: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008],