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Calpain 10 rabbit pAb
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ES4603
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Calpain 10 rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: CAPN10; KIAA1845; Calpain-10; Calcium-activated neutral proteinase 10; CANP 10
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Immunogen: Synthesized peptide derived from the N-terminal region of human Calpain 10.
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 75kD
GeneID: 11132
Human Swiss-Prot No: Q9HC96
Cellular localization: intracellular,cell,mitochondrion,cytosol,plasma membrane,
Background: Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq,