Products

R-cadherin rabbit pAb
One-click to copy product information
ES4408
Size： Price：
50 µL $148.00
100 µL $248.00
Manual Send email to us

Overview

Product name: R-cadherin rabbit pAb
Reactivity: Human;Mouse
Alternative Names: CDH4; Cadherin-4; Retinal cadherin; R-CAD; R-cadherin
Source: Rabbit
Dilutions: Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human CDH4. AA range:731-780
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Molecular Weight: 100kD
GeneID: 1002
Human Swiss-Prot No: P55283
Cellular localization: Cell membrane; Single-pass type I membrane protein.
Background: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],