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BMP-15 rabbit pAb
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ES4376
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50 µL $148.00
100 µL $248.00
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Overview

Product name: BMP-15 rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: BMP15; GDF9B; Bone morphogenetic protein 15; BMP-15; Growth/differentiation factor 9B; GDF-9B
Source: Rabbit
Dilutions: IHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human BMP15. AA range:291-340
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 45kD
GeneID: 9210
Human Swiss-Prot No: O95972
Cellular localization: Secreted.
Background: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016],