Products

Apaf-1 rabbit pAb
One-click to copy product information
ES4108
Size： Price：
50 µL $148.00
100 µL $248.00
Manual Send email to us

Overview

Product name: Apaf-1 rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: APAF1; KIAA0413; Apoptotic protease-activating factor 1; APAF-1
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human APAF1. AA range:501-550
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 135kD
GeneID: 317
Human Swiss-Prot No: O14727
Cellular localization: Cytoplasm .
Background: This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],