MACC1; Metastasis-associated in colon cancer protein 1; SH3 domain-containing protein 7a5
Source:
Rabbit
Dilutions:
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Immunogen:
The antiserum was produced against synthesized peptide derived from the Internal region of human MACC1. AA range:411-460
Storage:
-20°C/1 year
Clonality:
Polyclonal
Isotype:
IgG
Concentration:
1 mg/ml
Observed Band:
97kD
GeneID:
346389
Human Swiss-Prot No:
Q6ZN28
Cellular localization:
Cytoplasm . Nucleus . Mainly found in the cytoplasm in non-metastasizing tumors.
Background:
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009],
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