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PUMA rabbit pAb
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ES3285
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50 µL $148.00
100 µL $248.00
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Overview

Product name: PUMA rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis
Source: Rabbit
Dilutions: WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human PUMA. AA range:120-169
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 23kD
GeneID: 27113
Human Swiss-Prot No: Q9BXH1
Cellular localization: Mitochondrion . Localized to the mitochondria in order to induce cytochrome c release.
Background: This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],