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IgA rabbit pAb
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ES2594
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50 µL $148.00
100 µL $248.00
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Overview

Product name: IgA rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: IGHA1; Ig alpha-1 chain C region; IGHA2; Ig alpha-2 chain C region
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human IgA. AA range:227-276
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 38kD
GeneID: 3493/3494
Human Swiss-Prot No: P01876/P01877
Cellular localization: Secreted . Cell membrane .
Background: disease:A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.,function:Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.,PTM:3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.,similarity:Contains 3 Ig-like (immunoglobulin-like) domains.,subunit:Monomeric or polymeric.,