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GRB14 rabbit pAb
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ES2473
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Overview

Product name: GRB14 rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: GRB14; Growth factor receptor-bound protein 14; GRB14 adapter protein
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human GRB14. AA range:81-130
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 61kD
GeneID: 2888
Human Swiss-Prot No: Q14449
Cellular localization: Cytoplasm . Endosome membrane ; Peripheral membrane protein . Upon insulin stimulation, translocates to the plasma membrane. .
Background: The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],