| Product name: |
Frizzled-7 rabbit pAb |
| Reactivity: |
Human;Mouse |
| Alternative Names: |
FZD7; Frizzled-7; Fz-7; hFz7; FzE3 |
| Source: |
Rabbit |
| Dilutions: |
WB 1:500-2000;Flow Cyt 1:50-200;IF/ICC 1:100-500;ELISA 1:5000-20000 |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from human FZD7. AA range:45-94 |
| Storage: |
-20°C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Observed Band: |
64kD |
| GeneID: |
8324 |
| Human Swiss-Prot No: |
O75084 |
| Cellular localization: |
Cell membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions. . |
| Background: |
frizzled class receptor 7(FZD7) Homo sapiens Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008], |
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