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Frizzled-7 rabbit pAb
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ES2373
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Overview

Product name: Frizzled-7 rabbit pAb
Reactivity: Human;Mouse
Alternative Names: FZD7; Frizzled-7; Fz-7; hFz7; FzE3
Source: Rabbit
Dilutions: WB 1:500-2000;Flow Cyt 1:50-200;IF/ICC 1:100-500;ELISA 1:5000-20000
Immunogen: The antiserum was produced against synthesized peptide derived from human FZD7. AA range:45-94
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 64kD
GeneID: 8324
Human Swiss-Prot No: O75084
Cellular localization: Cell membrane ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2). Localized in recycling endosomes in other conditions. .
Background: frizzled class receptor 7(FZD7) Homo sapiens Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008],