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FAST rabbit pAb
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ES2328
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50 µL $148.00
100 µL $248.00
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Overview

Product name: FAST rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: FASTK; Fas-activated serine/threonine kinase; FAST kinase
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human FAST. AA range:361-410
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 61kD
GeneID: 10922
Human Swiss-Prot No: Q14296
Cellular localization: [Isoform 4]: Mitochondrion matrix . Colocalizes with mitochondrial RNA granules. .
Background: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008],