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Crk II rabbit pAb
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ES2052
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Crk II rabbit pAb
Reactivity: Human;Mouse;Rat;Monkey
Alternative Names: CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human CrkII. AA range:187-236
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 40kD
GeneID: 1398
Human Swiss-Prot No: P46108
Cellular localization: Cytoplasm . Cell membrane . Translocated to the plasma membrane upon cell adhesion. .
Background: This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008],