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Chr-A rabbit pAb
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ES1980
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Chr-A rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: CHGA; Chromogranin-A; CgA; Pituitary secretory protein I; SP-I
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human Chr-A. AA range:311-360
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 68kD
GeneID: 1113
Human Swiss-Prot No: P10645
Cellular localization: [Serpinin]: Secreted . Cytoplasmic vesicle, secretory vesicle . Pyroglutaminated serpinin localizes to secretory vesicle. .; Cytoplasmic vesicle, secretory vesicle . Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle . Secreted . Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. In pituitary gonadotropes, located in large secretory granules. .
Background: The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014],