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Cdc42EP5 rabbit pAb
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ES1932
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Cdc42EP5 rabbit pAb
Reactivity: Human;Mouse
Alternative Names: CDC42EP5; BORG3; CEP5; Cdc42 effector protein 5; Binder of Rho GTPases 3
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human BORG3. AA range:1-50
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 22kD
GeneID: 148170
Human Swiss-Prot No: Q6NZY7
Cellular localization: Endomembrane system ; Peripheral membrane protein . Cytoplasm, cytoskeleton .
Background: Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013],