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CD130/gp130 (Phospho-Ser782) rabbit pAb
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ES17738
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50 µL $148.00
100 µL $248.00
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Overview

Product name: CD130/gp130 (Phospho-Ser782) rabbit pAb
Reactivity: Human; Mouse
Alternative Names: Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta;IL-6R subunit beta;IL-6R-beta;IL-6RB;CDw130;Interleukin-6 signal transducer;Membrane glycoprotein 130;gp130;Oncostatin-M receptor subunit alpha;CD antigen CD130)
Source: Rabbit
Dilutions: IHC-p 1:50-200, WB 1:500-2000
Immunogen: Synthesized peptide derived from human CD130/gp130 (Phospho-Ser782)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 130kD
GeneID: 3572
Human Swiss-Prot No: P40189
Cellular localization: [Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .
Background: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014],