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Bcl-w rabbit pAb
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ES1760
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Bcl-w rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: BCL2L2; BCLW; KIAA0271; Bcl-2-like protein 2; Bcl2-L-2; Apoptosis regulator Bcl-W
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human BCLW. AA range:131-180
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 25kD
GeneID: 599
Human Swiss-Prot No: Q92843
Cellular localization: Mitochondrion membrane ; Peripheral membrane protein . Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.
Background: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010],