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IGF-I Receptor β (phospho-Tyr980) rabbit pAb
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ES15513
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50 µL $148.00
100 µL $248.00
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Overview

Product name: IGF-I Receptor β (phospho-Tyr980) rabbit pAb
Reactivity: Human;Mouse;Rat
Alternative Names: Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
Source: Rabbit
Dilutions: WB 1:1000-2000
Immunogen: Synthesized phosho peptide around human IGF-I Receptor β (Tyr980)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: pro: 155kD, recetor beta: 95kD
GeneID: 3480
Human Swiss-Prot No: P08069
Cellular localization: Cell membrane ; Single-pass type I membrane protein .
Background: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],