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Stat4 (phospho Tyr693) rabbit pAb
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ES1407
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Stat4 (phospho Tyr693) rabbit pAb
Reactivity: Human;Mouse;Rat;Monkey
Alternative Names: STAT4; Signal transducer and activator of transcription 4
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/5000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human STAT4 around the phosphorylation site of Tyr693. AA range:660-709
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 86kD
GeneID: 6775
Human Swiss-Prot No: Q14765
Cellular localization: Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
Background: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011],