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Trk B (Phospho-Y817) Polyclonal Antibody
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ES12559
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Trk B (Phospho-Y817) Polyclonal Antibody
Reactivity: Human; Mouse; Rat
Alternative Names: BDNF/NT-3 growth factors receptor (EC 2.7.10.1;GP145-TrkB;Trk-B;Neurotrophic tyrosine kinase receptor type 2;TrkB tyrosine kinase;Tropomyosin-related kinase B)
Source: Rabbit
Dilutions: IHC-p 1:50-200, WB 1:500-2000
Immunogen: Synthesized peptide derived from human Trk B (Phospho-Y817)
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 145kD
GeneID: 4915
Human Swiss-Prot No: Q16620
Cellular localization: Cell membrane ; Single-pass type I membrane protein . Endosome membrane ; Single-pass type I membrane protein . Early endosome membrane . Cell projection, axon . Cell projection, dendrite . Cytoplasm, perinuclear region . Cell junction, synapse, postsynaptic density . Internalized to endosomes upon ligand-binding. .
Background: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],