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Cleaved-MMP-3 (F100) rabbit pAb
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ES1049
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50 µL $148.00
100 µL $248.00
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Overview

Product name: Cleaved-MMP-3 (F100) rabbit pAb
Reactivity: Human;Rat;Mouse;
Alternative Names: MMP3; STMY1; Stromelysin-1; SL-1; Matrix metalloproteinase-3; MMP-3; Transin-1
Source: Rabbit
Dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Immunogen: The antiserum was produced against synthesized peptide derived from human MMP3. AA range:81-130
Storage: -20°C/1 year
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/ml
Observed Band: 43kD
GeneID: 4314
Human Swiss-Prot No: P08254
Cellular localization: Secreted, extracellular space, extracellular matrix .
Background: matrix metallopeptidase 3(MMP3) Homo sapiens Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008],