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a-actinin (4A12) Mouse mAb
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EM1261
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50 µL $148.00
100 µL $248.00
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Overview

Product name: a-actinin (4A12) Mouse mAb
Reactivity: Human, Rat, Mouse
Alternative Names: actinin 1 smooth muscle antibody, actinin alpha 1 antibody, ACTN 1 antibody, FLJ40884 antibody
Source: Mouse
Dilutions: IHC 1:100-200
Immunogen: Recombinant Protein
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Clonality: Monoclonal
Isotype: IgG1
Concentration: 1mg/mL
Observed Band: 103kDa
GeneID: 87
Human Swiss-Prot No: P12814
Cellular localization: Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane
Background: α-Actinin belongs to the spectrin family of cytoskeletal proteins. α-Actinin is necessary for the attachment of actin filaments to the Z-lines in skeletal muscle cells, and to the dense bodies in smooth muscle cells. The functional protein is an anti-parallel dimer, which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinated contractions between sarcomeres in the horizontal axis.