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Technical

NF-κB canonical signaling pathway
source:Technical divisiondate:2022-07-21views:176

 

NF-kB (k-hammer enhancement of nuclear factor-activated B cells) plays a key regulatory role in cytokine-induced gene expression, and it regulates genes encoding: acute phase response proteins, cytokines, cell adhesion molecules , immune regulatory molecules, viral oncogenes, growth factors, transcription and growth regulators, etc. By regulating the expression of various genes, NF-kB is involved in various biological processes such as immune response, inflammatory response, apoptosis, and tumorigenesis.

The NF-kB family consists of cRel, RelA (p65), RelB, NF-kB1 (p50), NF-kB2 (p52), and they all have Rel homology domains at the N-terminus, among which cReI, ReIA (p65) and ReIB has a transcription activation domain (TAD), which can positively regulate gene expression; p52 and p50 are cleaved from the precursor proteins p100 and p105, respectively, and the C-terminus of the precursor protein has a structure similar to NF-kB inhibitor (IκB) , as IkB-like proteins inhibit NF-kB function, and their homodimers can inhibit transcription.

 

 

 

Indicator name

reactivity

application

NFκB p65 mAb(5G6)

H.M.R

WB.IHC-p.IF/ICC.IP

NFκB-p65 pAb

H.M.R

WB.IHC-p.lF(P).IP.ELISA

NFκB-p65 (Thr505) pAb

H.M.R

WB.IHC-p.lF(P).ELISA

NFκB-p65 (Thr435) pAb

H.MRMκ

WB.IHC-p.IF(P).IP ELISA

NFκB-p65 (Thr254) pAb

H.M.R

WB.IHC-p.lF(P).IP ELISA

NFκB-p65 (Sec536) pAb

H.M.R.Mκ

IF/ICC.WB.IHC-p.IP.ELISA

NFκB-p65 (Ser529) pAb

H.M.R.Mκ

IF/ICC.WB.IHC-p.ELISA

NFκB-p65 (Ser468) pAb

H.M.R

WB.IHC-p.IF(P).IP ELISA

NFκB-p65 (Ser311) pAb

H.M

WB.IHC-p.IF/ICC.ELISA

NFκB-p65(Ser281)pAb

H.M.R

IHC-p.lF(P).ELISA

NFκB-p65 (Ser276) pAb

H.M.R

WB.IHC-p.lF(P).lP.ELISA

RelB (Ser552) pAb

H.M

WB.IHC-p.lF(P).ELISA

RelB pAb

H.M

WB.ELISA

c-Rel mAb

H.M

WB.IHC-p.IF/ICC.ELlSA

c-Rel pAb

H.R.M.

WB.IHC-p.lF(P).ELISA

c-Rel (Ser503) pAb

H.R.M.

WB.IHC-p.lF(P).ELISA

NF-κB P105/P50 M mAb(4D11)

H. M

IHC-p.WB

NFκB-p105/p50mAb

H

WB.IHC-p.IF/lCC.FCM.ELISA

NFκB-p105/p50pAb

H.M.R

IF/ICC.WB.IHC-p.ELISA

NFκB-p105/p50 (Ser337) pAb

H.M.R

WB.IHC-p.IF/ICC.ELISA

NFκB-p105(Ser932)pAb

H.M.R

WB.IHC-p.lF(P).ELISA

NFκB-p105(Ser927)pAb

H.M

WB.IHC-p.IF/ICC.ELISA

NFκ0-p105 (Ser907) pAb

H.R.M.

WB.IHC-p.lF(P).IP.ELISA

NFκB-p105 (Ser893) pAb

H.R.M.

WB.IHC-p.lF(P).ELISA

NF-κB p105 (Ser923) rabbit pAb

H.M

WB. ELISA

NF-κB p105 (Ser903) rabbit pAb

H.M

WB. ELISA

NF-κB p105 (Cleaved-Thr434) rabbit pAb

H.M

WB. ELISA

NF-κB p105 (Cleaved-Gly433) rabbit pAb

H.M

WB. ELISA

NF-κB2 p100 (-Ser866/870) rabbit pAb

H.M

WB

NFκB-p100 (Ser865) pAb

H.M.R

WB.IHC-p.IP.IF/lCC.ELISA

NFκB-p100 (Ser869) pAb

H.M.R

WB.IHC-p.lF(P).IP.ELISA

NFκB-p100 (Ser872) pAb

H.M

WB.ELISA

NFκB-p100 pAb

H.M.R

WB.IHC-p.IP.IF/ICC.ELISA

IKKα mAb

H

WB.IF/ICC.FCM.ELISA

IKKα/β pAb

H.M.R

WB.IHC-p.IF(P).ELISA

IKKα (Thr23) pAb

H.M.R

WB.IHC-p.lF(P).ELISA

IKKα pAb

H.M.R

WB.IHC-p.lF(P).ELISA

IKKα/β (Ser176/177) pAb

H.M.R

WB.IHC-p.IF(P).ELISA

IKKα/β (Ser180/181) pAb

H.M.R

WB.IHC-p.lF(P).ELISA

IKKβ pAb

H.M.R

WB.IHC-p.lF(P).ELlSA

IKKβ mAb

H

WB.IHC-p.lF(P).ELISA

IKKβ (lyr199) pAb

H.M.R

WB.IHC-p.IF(P).ELISA

IKKβ (Tyr188) pAb

H.M.R.Mκ

WB.IHC-p.IF(P).ELISA

IKKγ pAb

H.M.R

WB.IHC-p.lF(P).ELISA

IKKγ (Ser85) pAb

H.R.M.

WB.IHC-p.IF(P).ELlSA

IKKγ (Ser376) pAb

H.R.M.

IHC-p.IF(P).ELISA

IKKγ (Ser31) pAb

H.R.M.

WB.IHC-p.lF(P).ELISA

IκB α M mAb(2A5)

H. M.R

IHC-p.WB

IκB-α pAb

H.M.R

WB.IHC-p.IF/lCC.ELISA

IκBα (-Ser32) rabbit pAb

H.M.R

WB

lκB-α (Tyr42) pAb

H.M.R

WB.IHC-p.lF(P).ELISA

IκB-α (Tyr305) pAb

H.M.R.Mκ

WB.IHC-p.lF(P).ELISA

IκB-α (Ser32/S36) pAb

H.M.R.Mκ

WB.IHC-p.IF/ICC.ELISA

 

 

 

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