| Product name: |
NDUFA1 Polyclona Antibody |
| Reactivity: |
Human; Mouse; Rat |
| Alternative Names: |
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (Complex I-MWFE;CI-MWFE;NADH-ubiquinone oxidoreductase MWFE subunit) |
| Source: |
Rabbit |
| Dilutions: |
IHC-p 1:50-200, ELISA(peptide)1:5000-20000 |
| Immunogen: |
Synthesized peptide derived from human NDUFA1 AA range: 20-100 |
| Storage: |
-20°C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| GeneID: |
4694 |
| Human Swiss-Prot No: |
O15239 |
| Cellular localization: |
Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side . |
| Background: |
The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq, Jul 2008], |
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