| Product name: |
NEDD4 rabbit pAb |
| Reactivity: |
Human; Mouse;Rat |
| Source: |
Rabbit |
| Dilutions: |
WB 1：500-2000 |
| Immunogen: |
Synthesized peptide derived from human NEDD4 AA range: 80-130 |
| Storage: |
-20°C/1 year |
| Clonality: |
Polyclonal |
| Isotype: |
IgG |
| Concentration: |
1 mg/ml |
| Molecular Weight: |
145kD |
| GeneID: |
4734 |
| Human Swiss-Prot No: |
P46934 |
| Cellular localization: |
Cytoplasm . Cell membrane ; Peripheral membrane protein . Recruited to the plasma membrane by GRB10. Once complexed with GRB10 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). May be recruited to exosomes by NDFIP1. . |
| Background: |
This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016], |
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